Gregory Henderson Jr., a 46-year-old fugitive with ties to Louisville, has been added to the FBI's Ten Most Wanted Fugitives list. The FBI is offering a reward of up to $1,000,000 for information leading to his arrest. Henderson is alleged to have led a violent gang in Indianapolis with significant connections to the Sinaloa Cartel and the Gangster Disciples. He is charged with conspiracy to possess with intent to distribute and to distribute controlled substances, including cocaine, fentanyl, and methamphetamine, throughout Indianapolis and the surrounding region. Additionally, Henderson is accused of involvement in a dogfighting operation that resulted in the severe abuse and deaths of several dogs. A federal warrant was issued for his arrest in September 2025. The suspect is described as approximately 6 feet 1 inch tall, weighing between 160 and 220 pounds, with brown hair, brown eyes, a scar on his chin, and a tattoo on his back. The FBI warns that Henderson should be considered armed and dangerous. He has ties to several major cities, including Indianapolis, Louisville, Lexington, Cincinnati, Dayton, Chicago, and Detroit. The incident and ongoing manhunt are centered in the Louisville area, where Henderson has known connections. The FBI is urging anyone with information about Henderson's location to contact the agency immediately. Tips can be submitted by calling 1-800-CALL-FBI or by submitting a tip online through the FBI's official website. Authorities emphasize the seriousness of the charges and the potential danger Henderson poses to the public. The investigation remains active, and the FBI continues to seek public assistance in locating and apprehending the fugitive. This case highlights the ongoing efforts to combat organized crime and drug distribution networks in the Midwest. The reward underscores the importance of community involvement in bringing wanted individuals to justice. Henderson's alleged activities span multiple jurisdictions, indicating a broad operational scope. The FBI's involvement signifies the federal nature of the charges and the severity of the crimes. The public is reminded to exercise caution and report any suspicious activity to local law enforcement or the FBI tip line. The case remains open, and updates may be provided as the investigation progresses. The FBI's Ten Most Wanted list serves as a critical tool in tracking high-priority fugitives who pose significant threats to public safety.