The Opelousas Police Department is actively searching for Wayne Edward Angelle, who is wanted in connection with a homicide that occurred on Saturday evening, October 10, 2026. The incident took place near the intersection of Melancon Street and Jefferson Street in Opelousas, Louisiana. Angelle is considered armed and dangerous, and law enforcement officials have issued a strong public safety warning urging citizens not to approach, confront, or attempt to apprehend him under any circumstances. If observed, the public is instructed to immediately contact law enforcement or dial 911. Angelle faces multiple serious charges, including first-degree murder, illegal use of weapons or dangerous instrumentalities, possession of a firearm by a convicted felon, and theft of a motor vehicle. Chief Graig LeBlanc and the Opelousas Police Department are appealing to the community for assistance in locating the suspect. The department emphasizes that harboring or assisting someone wanted for a violent crime can result in serious legal consequences. All tips provided to the Opelousas Police Department, St. Landry Crime Stoppers, or through 911 can remain anonymous. The public is encouraged to share this information, as even a single piece of information could help bring justice to the victim’s family and protect the community from further violence. The investigation remains active, and additional details will be released as they become available. For those with information regarding Angelle’s whereabouts, the Opelousas Police Department can be reached at 337-948-2500, and St. Landry Crime Stoppers can be contacted at 337-948-TIPS. The department continues to urge anyone with knowledge of the suspect’s location to come forward immediately to ensure public safety and aid in the apprehension of the suspect.